Inorganic nanoparticles compositions in combination with ionizing radiations for treating cancer
AssigneeNanobiotix
InventorsElsa Borghi, Laurent Levy, Agnès Pottier
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Abstract
The present application relates to activable inorganic nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cancerous cells, tissues or organs. It more particularly relates to nanoparticles which can generate a surprisingly efficient therapeutic effect, when concentrated inside the tumor and exposed to ionizing radiations. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.
Claims12
A method for treating solid tumor cancer comprising administering to a human subject suffering from the solid tumor cancer by intra-tumoral injection a composition comprising a suspension of inorganic nanoparticles, determining the tumor volume, determining the volume of the composition comprising the inorganic nanoparticles within the tumor volume by radiography or computed tomography, and exposing the tumor of the human subject to ionizing radiation, wherein the inorganic nanoparticles provide more than 7×1022 electrons to the tumor, the inorganic material constituting the nanoparticles has a theoretical (bulk) density of at least 7 and an effective atomic number (Zeff) of at least 25, and the volume of the composition (Vc) occupies between 2% and 55% of the tumor volume.
Dependencies are inferred from the claim text.