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US 12,653,885 B2Granted
Polyomavirus neutralizing antibodies
AssigneeNovartis AG
InventorsJohanna Abend, Vanessa Cornacchione, John Michael Lindner, Elisabetta Traggiai
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Abstract
The present invention relates to anti-polyomavirus antibodies, antibody fragments, and their uses for the prevention and treatment of BK or JC virus infection and associated diseases.
Claims8
An isolated antibody or antigen binding fragment thereof that binds VP1, wherein said antibody comprises:
- (i) a heavy chain that comprises SEQ ID NO:294, and a light chain that comprises SEQ ID NO:
- 295;
- (ii) a heavy chain that comprises SEQ ID NO:296, and a light chain that comprises SEQ ID NO:
- 297;
- (iii) a heavy chain that comprises SEQ ID NO:298, and a light chain that comprises SEQ ID NO:
- 299;
- (iv) a heavy chain that comprises SEQ ID NO:300, and a light chain that comprises SEQ ID NO:
- 301;
- (v) a heavy chain that comprises SEQ ID NO:302, and a light chain that comprises SEQ ID NO:
- 303;
- or
- (vi) a heavy chain that comprises SEQ ID NO:304, and a light chain that comprises SEQ ID NO:
- 305.
10 more elements
Dependencies are inferred from the claim text.