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US 12,653,884 B2Granted
Anti-CD154 antibody having improved binding, functional and safety characteristics and use in human immunotherapy
AssigneeImmunext, Inc.
InventorsJay Rothstein, Robert George Edward Holgate, Arron Hearn
Life of this patent
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Abstract
Improved anti-CD 154 antibodies are provided herein which have improved therapeutic potency, in vivo half-life and ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation, transplant recipients, fibrosis and allergic disorders is disclosed herein.
Claims9
A nucleic acid which encodes for an antibody which binds to human CD154, which antibody comprises a variable heavy chain polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 and a variable light chain polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.