Peptide antigens and uses thereof
AssigneesHumanitas Mirasole S.P.A., Humanitas University
InventorsMarinos Kallikourdis, Elisa Martini, Gianluigi Condorelli
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Abstract
The invention provides a new method for identifying peptide antigens relevant to a non-autoimmune disease involving T cell activation as well as novel peptides identified therefrom. The isolated peptides of the invention are useful in the diagnosis, prevention and/or treatment of a cardiovascular disease, more specifically heart failure (HF). The invention further provides a pharmaceutical composition comprising at least one isolated peptide of the invention and a pharmaceutically acceptable carrier, vehicle, excipient and/or diluent. The pharmaceutical composition of the invention is suitable to be orally administered as a tolerizing vaccine.
Claims11
A method for treating a cardiovascular disease in an individual in need thereof, the method comprising:
- (a) providing a pharmaceutical composition comprising
- a peptide consisting of a sequence as set forth in SEQ ID NO. 1;
- (b) administering to the individual in need thereof the pharmaceutical composition of (a).
Dependencies are inferred from the claim text.