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US 12,653,842 B2Granted
Treatment of intervertebral disc degeneration
AssigneeKolon Tissuegene, Inc.
InventorsMoon Jong Noh, Hyun Bae, Sung Woo Kang, Kwan Hee Lee
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Abstract
The present application discloses a method for preventing or retarding degeneration of intervertebral disc at an intervertebral disc defect site, which includes injecting a mammalian connective tissue cell into the intervertebral disc defect site.
Claims11
A method for preventing or retarding degeneration of intervertebral disc at an intervertebral disc defect site of a mammal comprising:
- a) inserting a gene encoding a protein having intervertebral disc regenerating function into a mammalian cell to provide a transduced mammalian cell, and
- b) transplanting the transduced mammalian cell into the intervertebral disc defect site,
- wherein the protein is a TGF-B superfamily protein, and
- wherein the mammalian cell is a human embryonic kidney cell.
1 more element
A method for preventing or retarding degeneration of intervertebral disc at an intervertebral disc defect site of a mammal comprising:
- a) inserting a gene encoding a protein having intervertebral disc regenerating function into a first mammalian cell to produce a transduced first mammalian cell, and
- b) transplanting a mixture of the transduced first mammalian cell of a) and unmodified a second mammalian cell into the intervertebral disc defect site,
- wherein the protein is a TGF-ß superfamily protein, and
- wherein said first mammalian cell is a human embryonic kidney cell, and said second mammalian cell is a chondrocyte.
1 more element
Dependencies are inferred from the claim text.