Pharmaceutical compositions comprising nitroxoline lysinate, preparation method therefor and use thereof

A nitroxoline lysinate-containing pharmaceutical composition, characterized in that it comprises a first layer and a second layer;

• the first layer comprises 40% to 70% of an active pharmaceutical ingredient, 10% to 30% of a filler, 5% to 12% of a disintegrant, 0.5% to 2% of a lubricant, 0.1% to 1.5% of a glidant and 10% to 20% of an alkaline substance by weight, relative to the total weight of the first layer;
• wherein, the filler in the first layer is microcrystalline cellulose;
• the disintegrant in the first layer is crospovidone;
• the lubricant in the first layer is magnesium stearate;
• the glidant in the first layer is micronized silica gel;
• and the alkaline substance in the first layer is one or two selected from the group consisting of sodium bicarbonate and sodium carbonate;
• the second layer comprises 40% to 70% of an active pharmaceutical ingredient, 10% to 30% of a filler, 10% to 35% of a sustained release material, 0.1% to 2% of a lubricant and 0.1% to 2% of a glidant by weight, relative to the total weight of the second layer;
• wherein, the filler in the second layer is lactose monohydrate;
• the sustained release material in the second layer is hydroxypropyl methylcellulose K4M;
• the lubricant in the second layer is magnesium stearate;
• and the glidant in the second layer is micronized silica gel;
• and
• each of the active pharmaceutical ingredient in the first layer and the active pharmaceutical ingredient in the second layer is one or more independently selected from the group consisting of nitroxoline lysinate, a crystal form of nitroxoline lysinate, and a solvate of nitroxoline lysinate;
• and
• the mass ratio of the first layer to the second layer is 1:3 to 1:1.5.