Animal treatments
AssigneeNewMarket Pharmaceuticals LLC
InventorsDavid Rock, Mark Ridall
Life of this patent
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Abstract
Compositions and methods for the treatment and control of various conditions in an animal which comprises administering to said animal an effective amount of an immediate release composition of about 0.5% to 50% wt/wt of active ingredient together with excipients to a total of about 100%, wherein said composition dissolves in a relatively short period of time, e.g., 75 seconds or less, 5 seconds or less, or 3 seconds or less, upon administration to said animal.
Claims16
A method of treating a condition in an animal in need thereof, the method comprising:
- determining a dose of detomidine required;
- and
- administering orally to a pre-gastric mucosal cell of the animal a Direct Systemic Introduction (DSI) composition comprising the dose of detomidine;
- wherein the DSI composition in the animal's oral cavity is dissolved in less than about 75 seconds;
- and
- wherein the required dose of detomidine is determined by greater than 50% of the administered detomidine being detected in the animal's circulatory system via the pre-gastric mucosal cells lining the animal's alimentary canal prior to the animal's secretory stomach.
A freeze-dried Direct Systemic Introduction (DSI) composition comprising:
- an effective dose of detomidine adapted to exert a therapeutic effect on an animal when administered orally and absorbed via pre-gastric mucosa of the animal to obtain greater than 50% of the administered detomidine being detected in the animal's circulatory system, wherein the detomidine is present in the DSI composition in an amount ranging from about 0.5% to about 50% by weight of the overall composition;
- and
- wherein the DSI composition has an oral dissolution time of less than about 30 seconds.
Dependencies are inferred from the claim text.