TREM2 agonists for the stimulation of microglia and methods of identification
AssigneeThe Translational Genomics Research Institute
InventorsIsabelle Schrauwen, Matthew Huentelman, Wayne Jepsen
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Abstract
The present disclosure is directed to methods of promoting phagocytosis, particularly the phagocytic activity of microglia via activation of triggering receptor expressed on myeloid cells 2 (TREM2). The present disclosure is also directed to methods of activating TREM2 in a cell, particularly a neuronal cell exhibiting an accumulation of a pathogenic protein. The present disclosure is directed to detecting an effect of a compound on the TREM2 activity as well.
Claims9
A method of increasing phagocytosis of an apoptotic neuronal cell in a subject in need thereof, comprising administering to the subject Tyrphostin AG 538, or salts thereof, wherein the Tyrphostin AG 538, or salts thereof is administered in an amount sufficient to activate triggering receptor expressed on myeloid cells 2 (TREM2) in the subject.
Dependencies are inferred from the claim text.