Small molecule inhibitors of TLR2 signaling

A method of treating an inflammatory disease or condition in a subject consisting of administering to the subject a therapeutically effective amount of a compound selected from the group consisting of C29, ortho-vanillin, a salt of C29, a solvate of C29, a hydrate of C29, a prodrug of C29, a salt of ortho-vanillin, a solvate of ortho-vanillin, a hydrate of ortho-vanillin, a prodrug of ortho-vanillin, and a combination thereof, wherein the compound is administered in a composition comprising a pharmaceutically acceptable excipient, wherein the composition is administered by injection, wherein the inflammatory disease or condition is selected from the group consisting of sepsis, trauma, acute pancreatitis, acute respiratory distress syndrome, ischemia-reperfusion injury, cardiovascular disease, toxicity caused by chemotherapy, radiotherapy, or cytokine chemotherapy, burns and tumor metastasis.