Fixed combination medicine for the control and management of neuropathic pain

A fixed-dose combination drug product, presented in a solid, stable, and immediate-release dosage form, that comprises:

• (a) a therapeutically effective quantity from 12.5 to 75 mg/day of dexketoprofen trometamol as a non-steroidal anti-inflammatory drug (NSAID) or a pharmaceutically acceptable salt thereof;
• (b) a therapeutically effective quantity of a combination of B group/complex vitamins or their pharmaceutically accepted salts as an antineuritic agent;
• and
• (c) at least one pharmaceutically acceptable amount of a pharmaceutically acceptable excipient selected from the group of:
• diluents, binders, disintegrants emulsifiers or solubilizers, adsorbents and lubricants or a combination thereof,
• wherein the diluent is present and is corn starch in the range of 3.0-10% w/w,
• wherein the adsorbent is present and is aluminum and magnesium silicate in a pharmaceutically acceptable amount in the range of 0.5-90% w/w;
• wherein the combination of B group/complex vitamins comprises at least one of the following B complex vitamins:
• vitamin B12 (cyanocobalamin), vitamin B1 (thiamine) or its mononitrate salt, vitamin B6 (pyridoxine) or its hydrochloride salt, or a combination of any of these vitamins or their pharmaceutically acceptable salts;
• and
• wherein the immediate-release dosage form is selected from the group comprising tablets, pellets, caplets, granules, lozenges, pills, and capsules.