Preparation method of amisulpride tablet

A preparation method of an amisulpride tablet, comprising the following steps:

• S1, granulation:
• conducting wet granulation on amisulpride with a coating material to obtain wet granules;
• wherein the coating material comprises ethyl cellulose and hydroxypropyl cellulose at a mass ratio of 1:1;
• S2, coating:
• subjecting the wet granules obtained in step S1 to coating with additional coating material, drying, and sieving to obtain coated granules;
• wherein the additional coating material comprises the ethyl cellulose and the hydroxypropyl cellulose at a mass ratio of 1:1;
• S3, first mixing:
• mixing the coated granules obtained in step S2 with a hydrophilic lubricant to obtain a material 1;
• wherein the hydrophilic lubricant is sodium stearyl fumarate, and is added at 0.5% to 1.5% of the weight of the amisulpride tablet;
• S4, second mixing:
• adding an auxiliary material into the material 1 obtained in step S3, and mixing to obtain a material 2;
• wherein the auxiliary material comprises at least one of a disintegrant, a filler, a sweetener, or a flavoring agent, and does not comprise a lubricant;
• S5, total mixing:
• mixing the material 2 obtained in step S4 with a hydrophobic lubricant to obtain a total mixture;
• wherein the hydrophobic lubricant is magnesium stearate, and accounts for 0.5% to 1.5% of the weight of the amisulpride tablet;
• and
• S6, compressing:
• compressing the total mixture obtained in step S5 to obtain the amisulpride tablet.