Preparation of solid dosage forms comprising antibodies by solutions/suspension layering

A method for preparing a solid dosage form comprising i) an inert core unit;

• and ii) a drug coating, said drug coating comprising at least one antibody or functional fragment thereof as active agent, a buffer and at least one polymeric binder deposited on the inert core unit by drug layering;
• said method comprising the steps of:
• a) preparing an active agent coating liquid, comprising 1-50 mg/ml of the at least one antibody or functional fragment thereof, the buffer and the at least one polymeric binder, as an aqueous solution or suspension;
• b) layering the inert core unit with the active agent coating liquid of step (a) using spray coating;
• and
• c) drying the wet drug layered inert core unit, simultaneously with step b), or after step b) has been completed, to give rise to a dried solid dosage form.