Compositions and methods for administering a YAP1/WWRT1 inhibiting composition and a GLS1 inhibiting composition
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsAbhinav Prakash Acharya, Stephen Yu-Wah Chan, Steven R. Little
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Abstract
Disclosed are compositions comprising a YAP1/WWRT1 inhibiting agent and a glutaminase inhibiting agent and methods of their use. Disclosed herein are therapeutic particles comprising a biocompatible polymer, a YAP1/WWRT1 inhibiting agent, and a glutaminase inhibiting agent. In one aspect, disclosed herein are methods of treating a pulmonary disease in a subject in need of such treatment comprising administering the therapeutic particle to the subject.
Claims8
A method of treating a pulmonary disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a therapeutic particle, wherein the therapeutic particle comprises a biocompatible polymer and a composition comprising a YAP1/WWRT1 inhibiting agent and a glutaminase inhibiting agent, wherein the YAP1/WWRT1 inhibiting agent comprises verteporfin, and the glutaminase inhibiting agent comprises CB-839, a salt, prodrug, or derivative thereof, and wherein the therapeutic particle is inhaled and control-released to target a pulmonary vascular compartment.
Dependencies are inferred from the claim text.