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US 12,653,779 B2Granted
Compositions and methods for the treatment of presbyopia
AssigneeLenz Therapeutics Operations, Inc.
InventorGerald Horn
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Abstract
The invention provides compositions and methods for the treatment of presbyopia. The compositions comprise aceclidine hydrochloride, polysorbate 80, mannitol, anhydrous hypromellose, disodium edetate dihydrate, benzalkonium chloride, sorbic acid and anhydrous sodium citrate and optionally tropicamide.
Claims14
A method of treating presbyopia in a subject in need thereof, the method comprising:
- a. providing a stable aqueous ophthalmological composition comprising from about 1.25% to about 1.85% w/v aceclidine as the only ophthalmologically active agent in the stable aqueous ophthalmological composition, wherein the stable aqueous ophthalmological composition does not comprise an in situ gelling agent;
- b. storing the stable aqueous ophthalmological composition for 1 to 3 months at a temperature from about 2° C. to about 8° C., wherein a therapeutically effective amount of aceclidine remains in solution in the stable aqueous ophthalmogical composition for 1 to 3 months when stored at about 2° C. to about 8° C.;
- and
- c. administering the stable aqueous ophthalmological composition to an eye of the subject.
1 more element
Dependencies are inferred from the claim text.