Multimodal subcutaneous vasculature visualization and augmented reality overlays for hands-free clinical procedures

A system, comprising:

• an imaging system configured to acquire imaging data of tissue structure and anatomical structures of a patient;
• a processing circuitry comprising at least one processor and memory storing instructions that, when executed by the at least one processor, cause the processing circuitry to:
• segment anatomical structures in the imaging data;
• estimate a target depth and a target dimension for a target anatomical structure;
• compute a candidate access site and a trajectory comprising at least one of an insertion path and an incision path based on the segmentation and the estimated target depth and the estimated target dimension;
• and
• maintain adaptive overlay alignment by using a patient coordinate frame and a display coordinate frame, wherein the alignment is continuously updated to compensate for patient motion and device motion;
• and
• an extended-reality device, comprising a head-worn display and a projection module, configured to present patient-registered overlays through the head-worn display and to project the overlays onto patient skin using an adaptive calibration.