Apparatus and methods for tumor ablation
AssigneeAlpfa Medical, Inc.
InventorRaju Viswanathan
Life of this patent
Estimating the term…
Abstract
Systems, devices, and methods described herein relate to catheter devices for therapy delivery in tumor treatment applications. In some embodiments, a catheter device includes a shaft defining a lumen, and a needle device disposed in the lumen, the needle device having a distal portion that includes an exposed electrical conductor, where the distal portion of the needle device is configured to be extended out of the lumen. The needle device can be configured to receive a pulsed voltage waveform and to deliver a pulsed electric field via the exposed electrical conductor to ablate surrounding tissue.
Claims29
An apparatus, comprising:
- a shaft defining a lumen;
- a shaft electrode having a compressible geometry disposed around a distal portion of the shaft, the shaft electrode configured to transition between an unstressed state in which the shaft electrode has a first outer diameter greater than a diameter of the shaft and a stressed state in which the shaft electrode has a second diameter smaller than the first diameter;
- and
- a needle device disposed in the lumen, the needle device having a distal portion that includes an exposed electrical conductor and a proximal portion that is electrically insulated with insulation configured to withstand a voltage of at least about 500 Volts without dielectric breakdown,
- the distal portion of the needle device having a substantially straight geometry and configured to be inserted into target tissue,
- the shaft electrode and the needle device being configured to receive a pulsed voltage waveform and to deliver a pulsed electric field via the shaft electrode and the exposed electrical conductor to irreversibly electroporate the target tissue.
An apparatus, comprising:
- a shaft defining a lumen;
- a shaft electrode having a compressible geometry disposed around a distal portion of the shaft, the shaft electrode configured to transition between an unstressed state in which the shaft electrode has a first outer diameter greater than a diameter of the shaft and a stressed state in which the shaft electrode has a second diameter smaller than the first diameter;
- and
- a needle device disposed in the lumen, the needle device having a distal portion that includes an exposed electrical conductor,
- the distal portion of the needle device being configured to be extended out of the lumen at a non-zero angle with respect to a longitudinal axis of the shaft and to be inserted into target tissue,
- the shaft electrode and the needle device being configured to receive a pulsed voltage waveform and to deliver a pulsed electric field via the shaft electrode and the exposed electrical conductor to irreversibly electroporate the target tissue.
An apparatus, comprising:
- a shaft defining a lumen;
- a shaft electrode having a compressible geometry disposed around a distal portion of the shaft, the shaft electrode configured to transition between an unstressed state in which the shaft electrode has a first outer diameter greater than a diameter of the shaft and a stressed state in which the shaft electrode has a second diameter smaller than the first diameter;
- and
- a needle device disposed in the lumen, the needle device having a distal portion that includes an exposed electrical conductor,
- the distal portion of the needle device having a helical geometry and being configured to be inserted into target tissue,
- the shaft electrode and the needle device being configured to receive a pulsed voltage waveform and to deliver a pulsed electric field via the shaft electrode and the exposed electrical conductor to irreversibly electroporate the target tissue.
Dependencies are inferred from the claim text.