Apparatus, systems and methods for soft tissue ablation

A method, comprising:

• generating, using a pulse generator configured to be coupled to an ablation device, voltage pulse trains, each voltage pulse train including:
• a plurality of biphasic pulses, each biphasic pulse of the plurality of biphasic pulses including a positive phase, a negative phase, and an inter-phase delay separating the positive phase and the negative phase,
• successive biphasic pulses of the plurality of biphasic pulses being separated by a pulse-to-pulse delay such that the plurality of biphasic pulses is separated by a plurality of pulse-to-pulse delays, and
• the plurality of pulse-to-pulse delays including at least one of (1) an increasing sequence of pulse-to-pulse delays including a subset of successive pulse-to-pulse delays that progressively increase or (2) a decreasing sequence of pulse-to-pulse delays including a subset of successive pulse-to-pulse delays that progressively decrease;
• and
• delivering the voltage pulse trains to a plurality of electrode sets of the ablation device to apply pulsed field ablation to tissue by interleaving the plurality of biphasic pulses of the voltage pulse train being delivered to a first electrode set of the plurality of electrode sets with at least the voltage pulse train being delivered to a second electrode set of the plurality of electrode sets.