Atraumatically formed tissue compositions, devices and methods of preparation and treatment
AssigneeTissueMill Technologies LLC
InventorsThomas Andrew Davenport, Paul Mulhauser, Gregory C. Guinan
Life of this patent
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Abstract
A process and system provides for atraumatic preparation of morselized Tissue Particles (TP)s, such as Full Thickness Skin Graft Particles (FTSGPs), cartilage particles and other organ tissue particles, in a liquid medium. The resultant tissue product may be a suspension of Tissue Particles in an aqueous solution and containing highly viable cells and may be rapidly prepared at bedside or in the operating room and conveniently delivered to a patient through a syringe or similar applicator. The morselized Tissues Particles may be used for surgical applications including wound healing, cosmetic surgery, and orthopedic cartilage repairs.
Claims34
Tissue particles, harvested from a full thickness skin graft and randomly morselized repeatedly to a random size and shape in a continuous circulating stream of a solution and full thickness skin particles, while maintaining a cell viability of at least 60%, said particles having an average size as measured across a largest dimension selected from the group consisting of:
- about 0.35 mm to 1.25 mm, about 0.5 mm to about 1.00 mm, about 0.5 mm to about 0.75 mm, about 0.25 mm to about 0.75 mm, and about 0.50 mm.
Morselized tissue particles, having an average size as measured across a largest dimension of about 0.20 mm to 1.50 mm, and a viability of at least 60%,
- wherein the morselized tissue particles are formed using a device for processing organ tissue comprising:
- a pair of cutting devices supported in juxtaposition in a container, wherein at least one of the cutting devices is moveable with respect the other cutting device to slice tissue between thereof;
- wherein at least one of the cutting devices is fixed with respect the moveable cutting device;
- and
- wherein an agitation device causes a vortex propulsion movement of fluid and tissue through the space between juxtaposed cutting devices.
Viable tissue particles for treating a patient in need thereof, said tissue particles being harvested from a full thickness skin graft and randomly repeatedly morselized to a size and shape in a continuous circulating stream of a solution and full thickness skin particles, said continuous stream generated by an agitation device which produces a vortex propulsion between juxtaposed cutting devices, said particles having an average size as measured across a largest dimension selected from the group consisting of:
- about 0.35 mm to 1.25 mm, about 0.5 mm to about 1.00 mm, about 0.5 mm to about 0.75 mm, about 0.25 mm to about 0.75 mm, and about 0.50 mm.
Dependencies are inferred from the claim text.