Ultrasound-derived proxy for physical quantity
AssigneeSiemens Medical Solutions USA, Inc.
InventorsYassin Labyed, Andrzej Milkowski
Life of this patent
Estimating the term…
Abstract
For ultrasound-based proxy estimation with an ultrasound scanner, one or more ultrasound measurements are converted to a biomarker of a different modality, such as providing a measurement of a standard biomarker from histology or a lab test assay. The conversion uses a user-selected model, allowing for selection of one of various models relating ultrasound measurements to the biomarker. The ultrasound scan sequence may be optimized to the one or more biomarkers and the user-selected model. This improvement in use of ultrasound measurements relative to standard biomarkers may more likely result in acceptance of the less costly and more easily obtained ultrasound measures in diagnosis.
Claims19
A method for an ultrasound-based proxy estimation with an ultrasound scanner, the method comprising:
- receiving a user selection of a first conversion model for converting from one or more ultrasound measurements to a non-ultrasound biomarker of another modality;
- automatically defining a sequence of ultrasound transmissions that are configured to acquire the one or more ultrasound measurements required by the first conversion model;
- scanning, by the ultrasound scanner, a patient with the sequence of ultrasound transmissions;
- estimating, by the ultrasound scanner, one or more quantitative ultrasound values for the one or more ultrasound measurements from ultrasound data resulting from the scanning;
- converting, by the first conversion model, the one or more quantitative ultrasound values to a value for the non-ultrasound biomarker of the other modality for the patient, wherein the non-ultrasound biomarker has a different unity and/or scale than the one or more quantitative ultrasound values;
- and
- displaying the value for the non-ultrasound biomarker for the patient.
A method for an ultrasound-based proxy estimation with an ultrasound scanner, the method comprising:
- receiving a user selection of a first conversion model for converting a plurality of ultrasound quantitative measurements to an estimate of MR-PDFF for a liver study of a patient, the plurality of ultrasound quantitative measurements comprising at least attenuation coefficient (AC) and backscatter coefficient (BSC);
- defining a sequence of ultrasound transmissions to acquire ultrasound data based on the user selection of the first conversion model;
- scanning, by the ultrasound scanner, the patient with the sequence of ultrasound transmissions;
- estimating, by the ultrasound scanner, values for AC and BSC from the ultrasound data resulting from the scanning;
- converting, using the first conversion model, the values for AC and BSC to an estimated value for MR-PDFF for the patient;
- and
- displaying the estimated value for MR-PDFF for the patient.
A system for an ultrasound-based proxy estimation, the system comprising:
- a user input configured to receive user entry of one or more models relating ultrasound parameters to one or more non-ultrasound parameters, the one or more models being in a list of multiple models for the one or more non-ultrasound parameters;
- a transducer;
- a beamformer configured to transmit and receive sequences of pulses in a patient with the transducer, the sequences of pulses selected from a plurality of sequences of pulse based on the selected one or more models in order to acquire the ultrasound parameters;
- an image processor configured to generate a value for the one or more non-ultrasound parameters from values of the ultrasound parameters, wherein a value for a respective non-ultrasound parameter has a different unity and/or scale than values of the ultrasound parameters, wherein the values of the ultrasound parameters are estimated using the transmit and receive sequences of the pulses;
- and
- a display configured to display the score for an index of a disease activity based on the one or more non-ultrasound parameters.
Dependencies are inferred from the claim text.