System and method for non-invasive determination of intracranial pressure

One or more non-transitory computer readable media comprising computer readable program instructions embodied therein, the computer readable program instructions comprising a set of instructions that, when executed by at least one processor, cause the at least one processor to:

• in connection with at least one selected controlled force applied to an eye of a subject,
• process a first plurality of measurements associated with retinal arterial pulsation amplitude data taken from the eye of the subject at the at least one selected controlled force, wherein the retinal arterial pulsation amplitude data is taken as a retinal arterial pulsation amplitude time-varying signal at multiple locations of a segment of an artery in the eye of the subject and the first plurality of measurements are obtained by decomposing the retinal arterial pulsation amplitude time varying signal into at least two frequency components for each of the multiple locations of the segment of the artery in the eye of the subject, and form a first data basis comprising at least information associated with the at least two frequency components of the first plurality of measurements;
• process a second plurality of measurements associated with retinal venous pulsation amplitude data taken from the eye of the subject at the at least one selected controlled force, wherein the retinal venous pulsation amplitude data taken as a retinal venous pulsation amplitude time-varying signal at multiple locations of a segment of a vein in the eye of the subject and the second plurality of measurements are obtained by decomposing the retinal venous pulsation amplitude time varying signal into at least two frequency components for each of the multiple locations of the segment of the vein in the eye of the subject, and forming a second data basis comprising at least information associated with the at least two frequency components of the second plurality of measurements;
• determine each intracranial pressure of a first plurality of determined intracranial pressures from the retinal arterial pulsation amplitude data by a first trained model which has been trained to define a relationship between the intracranial pressure and primarily arterial venous pulsation data of the first data basis:
• determine each intracranial pressure of a second plurality of determined intracranial pressures from the retinal venous pulsation amplitude data by a second trained model which has been trained to define a relationship between the intracranial pressure and primarily retinal venous pulsation data of the second data basis;
• and
• determine the accuracy of the intracranial pressure by comparing the first and second pluralities of intracranial pressures.