Method and apparatus for detecting mycoplasma using 3-D quantitative phase image measurement
AssigneeTomocube, Inc.
InventorsJaephil Do, Sumin Lee, Hye-Jin Kim
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Abstract
Disclosed are a method and apparatus for detecting mycoplasma using the measurement of a 3-D quantitative phase image. The method of detecting mycoplasma may include generating a three-dimensional (3-D) quantitative phase image of a sample by characterizing the sample by making quantitative a phase shift derived from light that passes through the sample, and determining whether the sample has been infected with mycoplasma by analyzing behavioral characteristics of the generated 3-D quantitative phase image.
Claims7
A method of detecting mycoplasma by a computer device comprising at least one processor, the method comprising:
- generating, by the at least one processor, a three-dimensional (3-D) quantitative phase image of a sample by characterizing the sample by making quantitative a phase shift derived from light that passes through the sample;
- determining, by the at least one processor, whether the sample has been infected with mycoplasma by analyzing behavioral characteristics of the generated 3-D quantitative phase image;
- and
- generating, by the at least one processor, a 3-D fluorescent image of the sample based on a direct stain method,
- wherein determining whether the sample has been infected with mycoplasma comprises determining whether the sample has been infected with mycoplasma by further using results of an analysis of an overlapped image of the 3-D quantitative phase image and the 3-D fluorescent image.
A computer device comprising:
- at least one processor implemented to execute an instruction readable by the computer device,
- wherein the at least one processor
- generates a three-dimensional (3-D) quantitative phase image of a sample by characterizing the sample by making quantitative a phase shift derived from light that passes through the sample, and
- determines whether the sample has been infected with mycoplasma by analyzing behavioral characteristics of the generated 3-D quantitative phase image;
- and
- generates a 3-D fluorescent image of the sample based on a direct stain method,
- wherein determining whether the sample has been infected with mycoplasma comprises determining whether the sample has been infected with mycoplasma by further using results of an analysis of an overlapped image of the 3-D quantitative phase image and the 3-D fluorescent image.
Dependencies are inferred from the claim text.