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US 12,649,980 B2Granted
Three-dimensional surface for protein and small molecule microarrays
AssigneeThe Johns Hopkins University
InventorsJun O. Liu, Zhiqiang Cheng, Heng Zhu, Zufeng Guo, Hanjing Peng
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Abstract
Surface structures that enable the preparation of three-dimensional microarrays of proteins or small molecules or other types of macromolecules are disclosed. The three-dimensional microarrays possess higher sensitivity for detecting protein-macromolecule and small molecule-protein interactions in a high-throughput fashion.
Claims5
A three-dimensional microarray comprising a surface-modified substrate-comprising a scaffold having the following molecular structure:
- wherein m and n are each independently an integer from 1 to 1000.
Dependencies are inferred from the claim text.