Carotenoids for treating or preventing nausea

A therapeutic composition formulated for oral delivery comprising:

• a genetically engineered microbe that introduces a carotenogenic modification to synthesize an increased level of a C50 carotenoid compound relative to the level synthesized before the genetic engineering,
• the C50 carotenoid compound, and
• a pharmaceutically acceptable carrier,
• wherein the microbe and the C50 carotenoid compound are each in a therapeutically effective amount to reduce nausea, vomiting, food aversion, and/or loss of appetite;
• wherein the C50 carotenoid compound synthesized by the genetically engineered microbe is at least 20% w/w of the therapeutic composition, and
• wherein the therapeutic composition is a tablet, troche, gummy, or gel.