Compositions, devices, and methods for treating Fabry disease

An isolated double-stranded DNA molecule comprising a nucleotide sequence comprising a promoter operably linked to a precursor alpha-galactosidase A (GLA) coding sequence, wherein the precursor GLA coding sequence encodes a GLA fusion protein comprising a signal peptide comprising:

• (a) SEQ ID NO:
• 15 or a conservatively substituted variant thereof that is at least 95% identical to SEQ ID NO:
• 15, or
• (b) the signal peptide of SEQ ID NO:
• 1, or a conservatively substituted variant thereof that is at least 95% identical to SEQ ID NO:
• 1.