Composition for inhibiting growth of cancer stem cells, containing WDR34 inhibitor, and use thereof
AssigneeKorea Atomic Energy Research Institute
InventorsRae Kwon Kim, In Gyu Kim, Yeon Jee Kahm
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Abstract
The present invention relates to a composition for inhibiting the growth of cancer stem cells, and a use thereof. A WDR34 inhibitor of the present invention inhibits the conversion of cancer cells into cancer stem cells and exhibits activity of inhibiting self-renewal, invasion, and migration of cancer stem cells, and thus can be effectively used as a cancer cell growth or metastasis inhibitor or a cancer stem cell growth inhibitor.
Claims9
A method for inhibiting cancer stem cells of a cancer patient, comprising administering a composition comprising a WD repeat domain 34 (WDR34) inhibitor as an active ingredient, to a subject in need thereof,
- wherein the WDR34 inhibitor is an antisense oligonucleotide, short hairpin RNA (shRNA), or small interfering RNA (siRNA), and
- wherein the cancer is WDR34-overexpressing cancer selected from the group consisting of liver cancer, brain cancer, and lung cancer.
A method for assisting a radiation anticancer treatment, comprising administering a composition comprising a WD repeat domain 34 (WDR34) inhibitor as an active ingredient, to a subject in need thereof before or together with the radiation,
- wherein the WDR34 inhibitor is an antisense oligonucleotide, short hairpin RNA (shRNA), or small interfering RNA (siRNA), and
- wherein the cancer is WDR34-overexpressing cancer selected from the group consisting of liver cancer, brain cancer, and lung cancer.
Dependencies are inferred from the claim text.