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US 12,649,909 B2Granted
Citrate synthase variant and method for producing O-acetyl-L-homoserine or L-methionine using same
AssigneeCj Cheiljedang Corporation
InventorsJin Sook Chang, Seung Hyun Cho, Seo-Yun Kim, Jaemin Lee, Min Ji Baek, Imsang Lee
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Abstract
The present disclosure relates to a citrate synthase variant, a microorganism comprising the variant, and a method for producing O-acetyl-L-homoserine and L-methionine using the microorganism.
Claims20
A citrate synthase variant having citrate synthase activity,
- wherein the amino acid at position corresponding to position 415 of the polypeptide of SEQ ID NO:
- 1 is histidine,
- the amino acid at the position corresponding to position 241 of the polypeptide of SEQ ID NO:
- 1 is threonine, and
- the variant has an amino acid sequence at least 95% identical to SEQ ID NO:
- 1.
3 more elements
A polynucleotide encoding a citrate synthase variant having citrate synthase activity,
- wherein the amino acid at position corresponding to position 415 of the polypeptide of SEQ ID NO:
- 1 is histidine,
- the amino acid at the position corresponding to position 241 of the polypeptide of SEQ ID NO:
- 1 is threonine, and
- the variant has an amino acid sequence at least 95% identical to SEQ ID NO:
- 1.
3 more elements
A microorganism of the genus Corynebacterium, comprising
- (a) a citrate synthase variant having citrate synthase activity, wherein the amino acid at the position corresponding to position 415 of the polypeptide of SEQ ID NO:
- 1 is histidine, the amino acid at the position corresponding to position 241 of the polypeptide of SEQ ID NO:
- 1 is threonine, and the variant has an amino acid sequence at least 95% identical to SEQ ID NO:
- 1;
- or
- (b) a polynucleotide encoding the citrate synthase variant of (a).
3 more elements
Dependencies are inferred from the claim text.