Nerve bundle and production method of nerve bundle
AssigneeUniversity of Tsukuba
InventorsAiki Marushima, Akira Matsumura, Hiroki Bukawa, Yuji Matsumaru, Masao Koda, Hiroshi Ishikawa, Akihiro Ohyama, Junko Toyomura, Shohei Takaoka, Yosuke Shibao, Miho Watanabe, Tetsuya Abe
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Abstract
The object of this invention is to provide a method of producing a nerve bundle including efficiently extending axons of neural cells. As a solution to accomplish this end, neural cells are cultivated in the presence of feeder cells including at least one type of cells selected from vascular component cells and perivascular cells.
Claims27
A method of producing a cultivated neural tissue with a first set of length and width, the method comprising culturing a neural cell population differentiated from oral mesenchymal cells on a substrate surface,
- wherein a portion of the surface is covered by feeder cells before culturing,
- wherein the portion of the surface corresponds to a second set of length and width,
- wherein the feeder cells promote the neural cell population to grow into a cultured basic tissue with the second set of length and width through the culturing,
- wherein the cultivated tissue is produced by combining a plurality of the cultured basic tissues so that the width of the cultivated tissue is larger than the width of the cultured basic tissue.
Dependencies are inferred from the claim text.