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US 12,649,797 B2Granted
Human 4-1BB agonist antibodies and methods of use thereof
AssigneeBoard of Regents, The University of Texas System
InventorsMichael A. Curran, Renee Chin, Marie-Andrée Forget, Chantale Bernatchez
Life of this patent
Estimating the term…
Abstract
Isolated or recombinant monoclonal antibodies that bind to 4-1BB are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.
Claims19
An isolated monoclonal antibody, wherein the antibody specifically binds to 4-1BB and comprises:
- (a) a first VH CDR is identical to SEQ ID NO:
- 3;
- (b) a second VH CDR is identical to SEQ ID NO:
- 5;
- (c) a third VH CDR is identical to SEQ ID NO:
- 7;
- (d) a first VL CDR is identical to SEQ ID NO:
- 11;
- (e) a second VL CDR is identical to SEQ ID NO:
- 13;
- and
- (f) a third VL CDR is identical to SEQ ID NO:
- 15;
- or
- (a) a first VH CDR is identical to SEQ ID NO:
- 19;
- (b) a second VH CDR is identical to SEQ ID NO:
- 21;
- (c) a third VH CDR is identical to SEQ ID NO:
- 23;
- (d) a first VL CDR is identical to SEQ ID NO:
- 27;
- (e) a second VL CDR is identical to SEQ ID NO:
- 29;
- and
- (f) a third VL CDR is identical to SEQ ID NO:
- 31;
- or
- (a) a first VH CDR is identical to SEQ ID NO:
- 35;
- (b) a second VH CDR is identical to SEQ ID NO:
- 37;
- (c) a third VH CDR is identical to SEQ ID NO:
- 39;
- (d) a first VL CDR is identical to SEQ ID NO:
- 43;
- (e) a second VL CDR is identical to SEQ ID NO:
- 45;
- and
- (f) a third VL CDR is identical to SEQ ID NO:
- 47;
- or
- (a) a first VH CDR is identical to SEQ ID NO:
- 51;
- (b) a second VH CDR is identical to SEQ ID NO:
- 53;
- (c) a third VH CDR is identical to SEQ ID NO:
- 55;
- (d) a first VL CDR is identical to SEQ ID NO:
- 59;
- (e) a second VL CDR is identical to SEQ ID NO:
- 61;
- and
- (f) a third VL CDR is identical to SEQ ID NO:
- 63.
52 more elements
Dependencies are inferred from the claim text.