Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
AssigneeBioAtla, Inc.
InventorsJay M. Short, Gerhard Frey, Hwai Wen Chang
Life of this patent
Estimating the term…
Abstract
A polypeptide having a heavy chain variable region and/or light chain variable region that specifically binds to CTLA4 protein as well as antibodies and antibody fragments containing the heavy chain variable region and/or the light chain variable region that bind to CTLA4 protein. Pharmaceutical compositions and kits comprising the polypeptide or antibodies and antibody fragments containing the polypeptide are also provided.
Claims18
An anti-CTLA4 antibody or antibody fragment for use in a method for the treatment of small cell lung cancer, non-small cell lung cancer, renal cancer, liver cancer, melanoma, bladder cancer, cervical cancer, hepatic cancer, gastric cancer or kidney cancer in a patient with said cancer;
- said anti-CTLA-4 antibody or antigen binding antibody fragment comprising
- a heavy chain variable region including three complementarity determining regions, said regions having H1, H2, and H3 sequences, wherein:
- (SEQ ID NO:
- 1)
- (a) the H1 sequence is GFTFSHYTMH;
- (SEQ ID NO:
- 2)
- (b) the H2 sequence is FIX1YX2GNX3KX4X5AX6SX7KG;
- and
- (SEQ ID NO:
- 3)
- (c) the H3 sequence is TGWLGPFDX8,
- wherein X1 is S or D;
- X2 is D, H or I, X3 is N or Y;
- X4 is Y or I;
- X5 is Y or E;
- X6 is D or K;
- X7 is V or M;
- and X8 is Y or I;
- and
- a light chain variable region including three complementarity determining regions having L1, L2, and L3 sequences, wherein:
- (SEQ ID NO:
- 4)
- (a) the L1 sequence is RX9SQX10X11GSSYLA;
- (SEQ ID NO:
- 5)
- (b) the L2 sequence is GAFSRATGX12;
- and
- (SEQ ID NO:
- 6)
- (c) the L3 sequence is QQDGSSPWT,
- wherein X9 is A or I;
- X10 is Y, S or H;
- X11 is V or G;
- X12 is V or I.
Dependencies are inferred from the claim text.