Proteins that bind SP17 including fully-human anti-SP17 antibodies
AssigneeMedicovestor, Inc.
InventorSeah Lim
Life of this patent
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Abstract
This disclosure describes proteins that specifically bind human sperm protein 17 (Sp17) with nanomolar affinity and high specificity. These proteins include a recombinant human anti-Sp17 IgG that is suitable for use as a therapeutic antibody to treat cancers that ectopically express Sp17. Other Sp17-binding proteins are described including antibody fragments, antibody conjugates, and fusion proteins.
Claims20
A recombinant-antibody that specifically binds to human sperm protein 17 (anti-Sp17), comprising:
- a heavy chain comprising SEQ ID NO:
- 11;
- and
- a light chain comprising SEQ ID NO:
- 12.
A recombinant-antibody or antigen-binding fragment thereof, that specifically binds human sperm protein 17 (anti-Sp17), comprising two variable domains, wherein:
- the antibody or antigen-binding fragment thereof comprises a first variable domain that comprises a VH CDR1 region comprising SEQ ID NO:
- 5, a VH CDR2 region comprising SEQ ID NO:
- 6, and a VH CDR3 region comprising SEQ ID NO:
- 7;
- and
- wherein the antibody or antigen-binding fragment thereof comprises a second variable domain that comprises a VL CDR1 region comprising SEQ ID NO:
- 8, a VL CDR2 region comprising SEQ ID NO:
- 9, and a VL CDR3 region comprising SEQ ID NO:
- 10.
A recombinant-antibody or antigen-binding fragment thereof, that specifically binds human sperm protein 17 (anti-Sp17), comprising two variable domains,
- wherein the antibody or antigen-binding fragment thereof comprises a first variable domain that comprises SEQ ID NO:
- 3;
- and
- wherein the antibody or antigen-binding fragment thereof comprises a second variable domain that comprises SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.