Chimeric antigen receptor targeting BCMA and use thereof

A chimeric antigen receptor (CAR) comprising:

• a BCMA-binding domain;
• a transmembrane domain;
• a costimulatory domain;
• and an intracellular signal transduction domain,
• wherein the BCMA-binding domain includes an antibody specifically binding to BCMA or fragment thereof comprising:
• a heavy chain variable region comprising a CDR1 region represented by the amino acid sequence of SEQ ID NO:
• 1, a CDR2 region represented by the amino acid sequence of SEQ ID NO:
• 2 and a CDR3 region represented by the amino acid sequence of SEQ ID NO:
• 3;
• and
• a light chain variable region comprising a CDR1 region represented by the amino acid sequence of SEQ ID NO:
• 4, a CDR2 region represented by the amino acid sequence of SEQ ID NO:
• 5, and a CDR3 region represented by the amino acid sequence of SEQ ID NO:
• 6.