Immunocytokines for treatment of autoimmune and inflammatory conditions
AssigneeHorizon Therapeutics Ireland DAC
InventorsPartha S. Chowdhury, Yong Jun Liu, Shino Hanabuchi, Nazzareno Dimasi
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Abstract
The present disclosure is directed to fusion proteins comprising a Tumor Necrosis Factor α (TNFα) binding protein and an interleukin-10 (IL-10) molecule, methods of making the fusion proteins, and methods of treating or preventing autoimmune and inflammatory conditions using the fusion proteins.
Claims15
A fusion protein comprising a first and second domain, wherein the first domain comprises a Tumor Necrosis Factor α (TNFα) binding antibody, and wherein the second domain comprises interleukin-10 (IL-10), wherein the TNFα binding antibody comprises a heavy chain variable region (VH) comprising SEQ ID NO:
- 16 and a light chain variable region (VL) comprising SEQ ID NO:
- 17, and wherein the IL-10 comprises the sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.