Microorganism expressing vasoactive intestinal peptide, and use thereof
AssigneeMedytox Inc.
InventorsJi Yoon Song, Hyo Jeong Choi, Hyeon Jin Noh, Young Ha Park, Yi Reh Jung
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Abstract
Provided are a recombinant microorganism expressing a vasoactive intestinal peptide (VIP) gene, and a composition including the microorganism for preventing or treating a disease causing damage to the gastrointestinal tract.
Claims9
A recombinant microorganism of the genus Lactobacillus, in which a constitutive promoter and an exogenous gene are introduced and a protease is inactivated, wherein the exogenous gene is operably linked to the constitutive promoter and encodes a vasoactive intestinal peptide (VIP), wherein the inactivated protease is at least one selected from the group consisting of HtrA, PepN, ClpP, and Lon, and wherein the microorganism is Lactobacillus paracasei, Lactobacillus brevis, or Lactobacillus plantarum.
Dependencies are inferred from the claim text.