Back to results
US 12,649,752 B2Granted
Zirconium-89 oxine complex as a cell labeling agent for positron emission tomography
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsNoriko Sato, Haitao Wu, Gary L Griffiths, Peter L Choyke
Life of this patent
Estimating the term…
Abstract
The invention provides a method of preparing a 89Zr-oxine complex of the formula The invention also provides a method of labeling a cell with the 89Zr-oxine complex and a method for detecting a biological cell in a subject comprising administering the 89Zr-oxine complex to the subject.
Claims9
A kit for labeling a protein of a biological cell comprising
- (a) a first component comprising a solution of 89ZrCl4 in hydrochloric acid,
- (b) a second component comprising oxine and hydrochloric acid,
- (c) an alkaline solution comprising a base sodium bicarbonate in an amount effective to neutralize a mixture of components (a) and (b),
- (d) a nonionic surfactant, which is polysorbate 80;
- and
- (e) instructions for preparing a labeling agent by utilizing (a), (b), (c), and (d);
- wherein
- the kit further includes instructions to carry out labeling of the biological cell at a temperature of 16 to 26° C.
5 more elements
Dependencies are inferred from the claim text.