Adenosine analogs for the treatment of disease

A compound represented by Formula (II′):

• or a pharmaceutically acceptable salt thereof, wherein:
• R4′ is selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C8 carbocycle, and optionally substituted 3 to 8-membered heterocycle, wherein optional substituents on C1-C6 alkyl are independently selected at each occurrence from R7 and optional substituents on C3-C8 carbocycle and 3 to 8-membered heterocycle are independently selected from R8,
• R5′ is selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, —NO2, —CN, —NH2, and halogen;
• R6′ is selected from hydrogen, —C(O)(NR502), and optionally substituted C1-C3 alkyl, wherein optional substituents on C1-C3 alkyl are independently selected from R10,
• each R7, and R10 is independently selected at each occurrence from:
• fluorine, —OR30, —N(R30)2, —C(O)R30, —C(O) OR30, —OC(O) R30, —NO2, and —CN;
• and
• C3-6 carbocycle and 3- to 6-membered heterocycle each of which is optionally substituted with one or more substituents independently selected from halogen, —OR31, —N(R31)2, —NO2, —CN, and C1-3 alkyl;
• each R8 is independently selected at each occurrence from:
• halogen, —OR30, —N(R30)2, C(O) R30, —C(O) OR30, —OC (O) R30, —NO2, and —CN;
• and
• C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR30, —N(R30)2, —NO2, —CN, C3-6 carbocycle and 3- to 6-membered heterocycle;
• each R30 is independently selected at each occurrence from hydrogen, and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, —O—C1-6 alkyl, C3-6 carbocycle, and 3- to 6-membered heterocycle;
• each R31 is independently selected at each occurrence from hydrogen, and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, —O—C1-6 alkyl, C3-6 carbocycle, and 3- to 6-membered heterocycle, wherein the C3-6 carbocycle and 3- to 6-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen, —OH, —CN, —NO2, —NH2, —O—C1-6 alkyl, and —C1-6 alkyl;
• each R50 is independently selected at each occurrence from hydrogen, and C1-6 alkyl;
• and
• R12′ is selected from hydrogen, halogen, hydroxy, —NO2, —CN, —NH2, —O—C1-6 alkyl, and C1-6 alkyl, wherein the alkyl portion of —O—C1-6 alkyl, and C1-6 alkyl are optionally substituted with one or more substituents selected from halogen, —OH, —NH2, —NO2, —CN, —O—C1-6 alkyl, C3-6 carbocycle, and 3- to 6-membered heterocycle;
• wherein the C3-6 carbocycle and 3—to 6-membered heterocycle are each optionally substituted with one or more substituents selected from halogen, hydroxy, —NO2, —CN, —NH2, —O—C1-6 alkyl, and C1-6 alkyl.