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US 12,649,725 B2Granted
Synthesis of small molecules inspired by phomoxanthone A
AssigneeWorcester Polytechnic Institute
InventorsRameez Ali, Anita Mattson
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Abstract
Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane.
Claims2
A composition having the general formula:
- wherein R is the ester having the formula CO2R1, and R1 is selected from benzyl, trichloroethyl, and trichloromethyl;
- R′ is selected from:
- a hydrogen, a benzyl, a trifluoromethyl, and a cyclopropyl;
- R″ is selected from an alkyl, a vinyl, an aryl, a heteroaryl, and a phenyl acetylene;
- and
- the R, R′ and R″ selected based on an affinity for biomolecular targets of Phomoxanthone A.
3 more elements
Dependencies are inferred from the claim text.