Back to results
US 12,649,717 B2Granted
Cyanine-derived compound, preparation method therefor, and application thereof
AssigneeNanjing Genvivo Biotech Co., Ltd.
InventorsZhixing Chen, Zhongtian Yang, Liuju Li
Life of this patent
Estimating the term…
Abstract
Disclosed are a cyanine-derived compound, a preparation method therefor, and application thereof. The compound has the structure represented by formula (1), and the preparation method for the compound is further disclosed. The series of compounds of the present invention can be used as fluorescent markers for live-cell imaging analysis or flow cytometric analysis, solving problems of high toxicity, high cost and poor imaging effect of current.
Claims8
A cyanine derivative, having a structure represented by formula (1):
- wherein
- X is selected from —O— or —NH—;
- Z is selected from —C(O)— or —(CH2)m—;
- Y− is a biocompatible anion bromine ion, a chlorine ion, or an acetate ion;
- R1, R2, R3, and R4 are selected from hydrogen, halogen, substituted or unsubstituted C1-20 alkyl, substituted or unsubstituted C1-20 alkoxy, substituted or unsubstituted C6-30 aryl, C1-20 ester, or sulfonate, or any two adjacent groups of R1, R2, R3, and R4, together with a carbon atom bonded thereto, form an unsubstituted or substituted C3-10 aliphatic ring, C6-30 aromatic ring or C1-30 heteroaromatic ring, wherein a substituent is selected from halogen, alkyl, and alkoxy;
- n is an integer not less than 1;
- k is an integer of 1-3;
- and
- m is an integer of 1-6.
6 more elements
Dependencies are inferred from the claim text.