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US 12,649,714 B2Granted
Process and intermediates for preparation of omaveloxolone and salts thereof
AssigneeSicor Societa Italiana Corticosteroidi S.p.A.
InventorsTomislav Biljan, Ivana Sagud, Dubravka Pavlicic, Maja Matanovic Skugor
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Abstract
Disclosed is a process for the preparation of Omaveloxolone and salts thereof, as well as intermediates thereof.
Claims8
A process for preparation of Omaveloxolone or a salt thereof, comprising:
- (a) Hofmann rearrangement reaction of a compound of Formula VII with PIFA or PIDA, in a solvent selected from ethers, ketones, nitriles, and combinations thereof, wherein the reaction is carried out in anhydrous conditions:
- to form a compound of formula IV:
- and
- (b) converting the compound of formula IV to Omaveloxolone.
1 more element
A process for preparation of Omaveloxolone or a salt thereof, comprising:
- (a) Hofmann rearrangement reaction of a compound of Formula VII with PIFA in anhydrous tetrahydrofuran:
- to form a compound of formula IV:
- and
- (b) converting the compound of formula IV to Omaveloxolone.
1 more element
Dependencies are inferred from the claim text.