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US 12,649,709 B2Granted
Naphthoquinone-based chalcone derivatives and uses thereof
OwnerRobert F. Hofmanninventor
Life of this patent
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Abstract
The present disclosure provides compounds of formula 1 to inhibit or prevent mitochondrial dysfunction by augmenting mitochondrial function. Mitochondrial dysfunction is the hallmark of a wide range of diseases and disorders. Mitochondria are a promising therapeutic target for the detection, prevention and treatment of various human diseases such as cancer, neurodegenerative diseases, ischemia-reperfusion injury, diabetes and obesity.
Claims13
A composition comprising:
- a compound of formula 1
- wherein:
- R is —H, —CH3, —C2H5, alkyl —CnH2n+1 (where n is an integer from 3-x), or —OH;
- R1 and R2 are independently —H, —CH3, —C2H5, —OCH3, alkyl —CnH2n+1 (where n is an integer from 3 to x), —OH, phenyl —C6H5, naphthyl, or an amino acid.
1 more element
Dependencies are inferred from the claim text.