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US 12,649,031 B2Granted
Methods for delivering agents with pre-filled syringes to minimize intraocular inflammation
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsNilsen Miller, Trevor Langley
Life of this patent
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Abstract
A method of treating an eye disorder in a patient that may include administering a medicament to the patient with a prefilled syringe, wherein the administration of the medicament with the prefilled syringe is configured to treat the eye disorder and decrease a rate of likelihood of an ocular infection to the patient's eye.
Claims32
A method of treating an eye disorder in a patient, the method comprising:
- administering a medicament to the patient with a prefilled syringe, wherein the administration of the medicament with the prefilled syringe is configured to treat the eye disorder and decrease a rate of likelihood of an ocular infection to the patient's eye;
- wherein the prefilled syringe includes:
- a body configured to store the medicament;
- a flange coupled to the body and including a first side opening and a second side opening, wherein the first side opening is a hole and the second side opening is a slot;
- a plunger rod coupled to the flange and including a proximal end portion and a distal end portion disposed partially inside the body;
- a protrusion extending from the proximal end portion of the plunger rod;
- and
- an extension, longitudinally aligned with the protrusion, protruding distally from the proximal end portion of the plunger rod;
- wherein a portion of the extension is configured to be received by the first side opening to restrict proximal movement of the plunger rod relative to the flange prior to the administering step and removed from the first side opening during the administering step;
- and
- wherein the protrusion is configured to be positioned outside of the second side opening prior to the administering step and received in the second side opening to restrict distal movement of the plunger rod relative to the flange during the administering step.
8 more elements
A method of reducing a probability of an occurrence of an ocular infection in a patient being treated for an eye disorder with a medicament, the method comprising:
- administering the medicament to the patient's eye via a pre-filled syringe;
- wherein the pre-filled syringe includes:
- a body;
- a plunger rod disposed partially inside the body and including an actuation portion;
- a blocking component coupled to a proximal end portion of the body;
- a protrusion extending laterally from the actuation portion;
- wherein the plunger rod further includes an extension, longitudinally aligned with the protrusion, protruding distally from the actuation portion, and the blocking component includes a first side opening and a second side opening, wherein the first side opening is a hole and the second side opening is a slot;
- wherein a portion of the extension is configured to be received by the first side opening to restrict proximal movement of the plunger rod relative to the blocking component prior to the administering step, and removed from the first side opening during the administering step;
- and
- wherein the protrusion is configured to be positioned outside of the second side opening prior to the administering step and received by the second side opening to restrict distal movement of the plunger rod relative to the blocking component during the administering step.
7 more elements
A method of reducing intraocular inflammation in a patient receiving an injection, the method comprising:
- administering the injection to the patient via a prefilled syringe including a medicament configured to treat an eye disorder, wherein the administration reduces a rate of likelihood of the patient developing an intraocular infection in response to the injection from the pre-filled syringe as compared to patients receiving the injection from non-prefilled syringes;
- wherein the prefilled syringe includes:
- a body;
- a plunger rod including a proximal end portion and a distal end portion disposed partially inside the body;
- and
- a flange piece;
- wherein the plunger rod includes a protrusion extending from the proximal end portion and an extension, longitudinally aligned with the protrusion, protruding distally from the proximal end portion, and wherein the flange piece includes a first side opening and a second side opening, wherein the first side opening is a hole and the second side opening is a slot;
- wherein, when a portion of the extension is received by the first side opening, proximal movement of the plunger rod relative to the flange piece is prevented, and the portion of the extension is configured to exit the first side opening during administration of the injection;
- wherein, when the protrusion is received by the second side opening, distal movement of the plunger rod relative to the flange piece is prevented, and the protrusion is configured to move from outside of the flange piece into the second side opening during administration of the injection.
6 more elements
Dependencies are inferred from the claim text.