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US 12,649,021 B2Granted
Apparatus for extracorporeal treatment of blood including calculation of pre-blood pump infusion flow rate
AssigneeGambro Lundia AB
InventorDominique Pouchoulin
Life of this patent
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Abstract
An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit (10) is configured calculate set values of two or more of the fluid flow rates based on a fluid flow rate set by the operator and on a prescribed dose value (Dset).
Claims21
An apparatus for extracorporeal treatment of blood comprising:
- a filtration unit including a primary chamber and a secondary chamber separated by a semi-permeable membrane;
- a blood withdrawal line in fluid communication with an inlet of the primary chamber, and a blood return line in fluid communication with an outlet of the primary chamber, said blood lines configured for connection to a patient cardiovascular system;
- a blood pump configured to control a flow of blood through the blood lines;
- an effluent fluid line in fluid communication with an outlet of the secondary chamber;
- a dialysis fluid line in fluid communication at one end thereof with an inlet of the secondary chamber;
- a pre-blood pump infusion line in fluid communication at one end thereof with the blood withdrawal line in a region of the blood withdrawal line positioned upstream of the blood pump;
- a post-dilution infusion fluid line in fluid communication at one end thereof with the blood return line;
- a container in fluid communication with an end of said pre-blood pump infusion line;
- fluid flow regulators for regulating flow through said fluid lines comprising at least a dialysis fluid pump for regulating flow through said dialysis fluid line, at least a pre-blood infusion pump for regulating flow through said pre-blood pump infusion line, and an effluent fluid pump for regulating flow through said effluent fluid line;
- a user interface for receiving entries from an operator;
- and
- a control unit operably connected to the user interface and the fluid flow regulators, the control unit configured to:
- receive, as a first entry via the user interface, a set value for a blood flow (QBLOOD) through the blood withdrawal or blood return line,
- receive, as a second entry via the user interface, a set value for a fluid removal rate (Qpfr) from the patient,
- receive, as a third entry via the user interface, a set value for a prescribed dose (Dset) to be delivered, wherein the prescribed dose (Dset) is a diffusive dose (Ddial) with a flow rate (Qdial) of fluid supplied to the filtration unit secondary chamber through the dialysis fluid line,
- calculate set values of a second flow rate and a third flow rate based on said set value for the fluid removal rate (Qpfr) from the patient set by the operator and on said prescribed dose value (Dset), wherein calculating the set values of the second flow rate and the third flow rate comprises:
- calculating a fluid flow rate (Qeff) through the effluent fluid line based on said set value for the fluid removal rate (Qpfr) from the patient set by the operator and said prescribed dose value (Dset) set by the operator, and
- calculating a fluid flow rate (Qrep2) through the post-dilution infusion fluid line,
- receive (i) a concentration (Ccitrate) of an anticoagulant present in the container in fluid communication with the end of said pre-blood pump infusion line, and (ii) a prescribed dose for said anticoagulant (Dset-citrate) to be delivered to the patient during the extracorporeal treatment,
- calculate a set value for a fluid flow rate (Qpbp) through said pre-blood pump infusion line as a function of:
- the set value of blood flow rate (QBLOOD),
- the concentration (Ccitrate) of the anticoagulant present in the container in fluid communication with the end of said pre-blood pump infusion line, and
- the prescribed dose for said anticoagulant (Dset-citrate) to be delivered through said pre-blood pump infusion line, and
- after calculating the fluid flow rate (Qpbp) through said pre-blood pump infusion line, calculate the fluid flow rate (Qeff) through the effluent fluid line as sum of the fluid flow rate (Qrep2) through the post-dilution infusion fluid line, the fluid removal rate (Qpfr) from the patient, the flow rate (Qdial) of fluid supplied to the filtration unit secondary chamber through the dialysis fluid line, and the fluid flow rate (Qpbp) through said pre-blood pump infusion line,
- wherein the control unit is further configured to control the blood pump, the dialysis fluid pump, the pre-blood infusion pump, the effluent fluid pump, and a post-dilution pump based on the set value of the blood flow rate (QBLOOD), the flow rate (Qdial) of fluid supplied to the filtration unit secondary chamber through the dialysis fluid line, the fluid flow rate (Qpbp) through the pre-blood pump infusion line, the fluid flow rate (Qeff) through the effluent fluid line, and the fluid flow rate (Qrep2) through the post-dilution infusion fluid line, respectively.
22 more elements
An apparatus for extracorporeal treatment of blood comprising:
- a filtration unit including a primary chamber and a secondary chamber separated by a semi-permeable membrane;
- a blood withdrawal line in fluid communication with an inlet of the primary chamber, and a blood return line in fluid communication with an outlet of the primary chamber, said blood lines configured for connection to a patient cardiovascular system;
- a blood pump configured to control a flow of blood through the blood lines;
- an effluent fluid line in fluid communication with an outlet of the secondary chamber;
- a waste container in fluid communication with an end of the effluent fluid line;
- a dialysis fluid line in fluid communication at one end thereof with an inlet of the secondary chamber;
- a first container of fresh fluid in fluid communication with an end of the dialysis fluid line;
- a pre-blood pump infusion line in fluid communication at one end thereof with the blood withdrawal line in a region of the blood withdrawal line positioned upstream of the blood pump;
- a second container in fluid communication with an end of said pre-blood pump infusion line and including a citrate based solution;
- a post-dilution infusion fluid line in fluid communication at one end thereof with the blood return line;
- a syringe container leading to said post-dilution infusion fluid line and including an ionic balance solution including a calcium ion based solution;
- fluid flow regulators for regulating flow through said fluid lines comprising a dialysis fluid pump for regulating flow through said dialysis fluid line, a pre-blood infusion pump for regulating flow through said pre-blood pump infusion line, a syringe pump operable with the syringe container, and an effluent fluid pump for regulating flow through said effluent fluid line;
- a user interface for receiving entries from an operator;
- and
- a control unit operably connected to the user interface and the fluid flow regulators, the control unit configured to:
- receive, as a first entry via the user interface, a set value for a blood flow (QBLOOD) through the blood withdrawal or blood return line,
- receive, as a second entry via the user interface, a set value for a fluid removal rate (Qpfr) from the patient,
- receive, as a third entry via the user interface, a set value for a prescribed dose (Dset) to be delivered, wherein the prescribed dose (Dset) is a diffusive dose (Ddial) with a flow rate (Qdial) of fluid supplied to the filtration unit secondary chamber through the dialysis fluid line,
- calculate set values of a second flow rate and a third flow rate based on said set value for the fluid removal rate (Qpfr) from the patient set by the operator and on said prescribed dose value (Dset), wherein calculating the set values of the second flow rate and the third flow rate comprises:
- calculating a fluid flow rate (Qeff) through the effluent fluid line based on said set value for the fluid removal rate (Qpfr) from the patient set by the operator and said prescribed dose value (Dset) set by the operator, and
- calculating a fluid flow rate (Qrep2) through the post-dilution infusion fluid line,
- receive (i) a concentration (Ccitrate) of the citrate based solution present in the second container, and (ii) a prescribed dose for said citrate based solution (Dset-citrate) to be delivered to the patient during the extracorporeal treatment,
- calculate a set value for a fluid flow rate (Qpbp) through said pre-blood pump infusion line as a function of:
- the set value of blood flow rate (QBLOOD),
- the concentration (Ccitrate) of the citrate based solution present in the second container, and
- the prescribed dose for said citrate based solution (Dset-citrate) to be delivered through said pre-blood pump infusion line, and
- after calculating the fluid flow rate (Qpbp) through said pre-blood pump infusion line, calculate the fluid flow rate (Qeff) through the effluent fluid line as sum of the fluid flow rate (Qrep2) through the post-dilution infusion fluid line, the fluid removal rate (Qpfr) from the patient, the flow rate (Qdial) of fluid supplied to the filtration unit secondary chamber through the dialysis fluid line, and the fluid flow rate (Qpbp) through said pre-blood pump infusion line,
- wherein the control unit is further configured to control the blood pump, the dialysis fluid pump, the pre-blood infusion pump, and the effluent fluid pump based on the set value of the blood flow rate (QBLOOD), the flow rate (Qdial) of fluid supplied to the filtration unit secondary chamber through the dialysis fluid line, the fluid flow rate (Qpbp) through said pre-blood pump infusion line, and the fluid flow rate (Qeff) through the effluent fluid line, respectively.
25 more elements
An apparatus for extracorporeal treatment of blood comprising:
- a filtration unit including a primary chamber and a secondary chamber separated by a semi-permeable membrane;
- a blood withdrawal line in fluid communication with an inlet of the primary chamber, and a blood return line in fluid communication with an outlet of the primary chamber, said blood lines configured for connection to a patient cardiovascular system;
- a blood pump configured to control a flow of blood through the blood lines;
- an effluent fluid line in fluid communication with an outlet of the secondary chamber;
- a dialysis fluid line in fluid communication at one end thereof with an inlet of the secondary chamber;
- a pre-blood pump infusion line in fluid communication at one end thereof with the blood withdrawal line in a region of the blood withdrawal line positioned upstream of the blood pump;
- a first container in fluid communication with an end of said pre-blood pump infusion line and including an anticoagulant;
- a post-dilution infusion fluid line in fluid communication at one end thereof with the blood return line;
- a second container leading to said post-dilution infusion fluid line and including an ionic balance solution;
- fluid flow regulators for regulating flow through said fluid lines comprising at least a dialysis fluid pump for regulating flow through said dialysis fluid line, at least a pre-blood infusion pump for regulating flow through said pre-blood pump infusion line, and an effluent fluid pump for regulating flow through said effluent fluid line;
- a user interface for receiving entries from an operator;
- and
- a control unit operably connected to the user interface and the fluid flow regulators, the control unit configured to:
- receive, as a first entry via the user interface, a set value for a blood flow (QBLOOD) through the blood withdrawal or blood return line,
- receive, as a second entry via the user interface, a set value for a fluid removal rate (Qpfr) from the patient,
- receive, as a third entry via the user interface, a set value for a prescribed dose (Dset) to be delivered, wherein the prescribed dose (Dset) is a prescribed dose (Dset-citrate) for said anticoagulant to be delivered through said pre-blood pump infusion line during the extracorporeal treatment,
- calculate set values of a second flow rate and a third flow rate based on said set value for the fluid removal rate (Qpfr) from the patient set by the operator and on said prescribed dose value (Dset), the control unit configured to calculate the fluid flow rate (Qpbp;
- Qrep2) through said pre-blood pump infusion fluid line and through said post-dilution infusion fluid line based on pre-defined algorithms, wherein calculating the set values of the second flow rate and the third flow rate comprises:
- calculating a fluid flow rate (Qeff) through the effluent fluid line based on said set value for the fluid removal rate (Qpfr) from the patient set by the operator and said prescribed dose value (Dset) set by the operator, and
- calculating a fluid flow rate (Qrep2) through the post-dilution infusion fluid line,
- wherein the pre-defined algorithm for the fluid flow rate (Qpbp) through said pre-blood pump infusion line is a function of:
- the set value of flow rate of blood or of plasma (QBLOOD;
- QPLASMA),
- a concentration (Ccitrate) of said anticoagulant present in the first container, and
- the prescribed dose for said anticoagulant (Dset-citrate) to be delivered through said pre-blood pump infusion line, and
- after calculating the fluid flow rate (Qpbp) through said pre-blood pump infusion line, calculate the fluid flow rate (Qeff) through the effluent fluid line as sum of the fluid flow rate (Qrep2) through the post-dilution infusion fluid line, the fluid removal rate (Qpfr) from the patient, the flow rate (Qdial) of fluid supplied to the filtration unit secondary chamber through the dialysis fluid line, and the fluid flow rate (Qpbp) through said pre-blood pump infusion line,
- wherein the control unit is further configured to control the blood pump, the dialysis fluid pump, the pre-blood infusion pump, and the effluent fluid pump based on the set value of the blood flow rate (QBLOOD), the flow rate (Qdial) of fluid supplied to the filtration unit secondary chamber thorough the dialysis fluid line, the fluid flow rate (Qpbp) through said pre-blood pump infusion line, and the fluid flow rate (Qeff) through the effluent fluid line, respectively.
24 more elements
Dependencies are inferred from the claim text.