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US 12,649,015 B2Granted
Embolization hydrogel having controllable degradation time, and preparation method therefor
AssigneeNextbiomedical Co., Ltd.
InventorsDon Haeng Lee, Eun Hye Lee, Yi Xian Li, Se Yun Kim, Dae Sung Lee
Life of this patent
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Abstract
The present invention relates to: an amorphous of spherical embolisation hydrogel having a degradation time that can be precisely controlled in blood vessels; and a preparation method therefor.
Claims18
An embolic composition comprising hydrogel microparticles prepared without using a cross-linking agent;
- wherein the hydrogel microparticles are configured such that particles can be produced by thermal denaturation;
- wherein the hydrogel microparticles are swollen by a solvent with a δP polar value of 14 or higher;
- wherein degradation time in vivo of the hydrogel microparticles is adjusted by washing;
- and
- wherein the washing is performed using a solvent with a 8P polar value of 14 or higher.
2 more elements
A method of preparing hydrogel microparticles prepared through step (a) or step (b):
- (a)
- 1) Preparing an aqueous solution of a biocompatible polymer;
- 2) adding an organic solvent to the aqueous solution of the biocompatible polymer of step 1) so as to be emulsified in order to form micro-sized particles;
- 3) Washing and drying the micro-sized particles prepared in step 2) to obtain micro-sized microparticles;
- 4) Thermally curing the micro-sized microparticles of step 3);
- and
- 5) washing, dehydrating, and drying the micro-sized microparticles obtained in step 4);
- or
- (b)
- 1) Preparing an aqueous solution of a biocompatible polymer;
- 2) stirring and/or low-temperature curing the aqueous solution of the biocompatible polymer of step 1) to form a foam and freeze-drying the foam;
- 3) Thermally curing the foamy material of step 2) to obtain micro-sized microparticles;
- 4) Washing and freeze-drying the micro-sized microparticles obtained in step 3);
- and
- 5) crushing the foamy material obtained in step 4) to obtain micro-sized microparticles.
12 more elements
Dependencies are inferred from the claim text.