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US 12,648,987 B2Granted
Alkaline phosphatase agents for treatment of radiation disorders
AssigneeTheriva Biologics, Inc.
InventorsMichael Kaleko, Christian Furlan Freguia, Sheila Connelly
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Abstract
The present invention relates to, inter alia, compositions and methods, including therapeutic alkaline phosphatases that find use in the treatment or prevention of the effects of radiation exposure and/or chemotherapy.
Claims15
A method of treating or preventing acute radiation enteropathy in a subject in need thereof, the method comprising administering to the subject an intestinal alkaline phosphatase (IAP), wherein the IAP comprises the amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO:
- 3, and wherein the acute radiation enteropathy comprises one of more of gastrointestinal syndrome, hematopoietic syndrome, neurovascular syndrome, and ionizing radiation induced apoptosis tissue damage.
Dependencies are inferred from the claim text.