Generation of neurons by reprogramming of oligodendrocytes and oligodendrocyte precursor cells

A vector comprising a polynucleotide encoding an antisense RNA or an interfering RNA that hybridizes to a polynucleotide encoding a human polypyrimidine tract binding protein 1 (PTBP1), wherein the antisense RNA or interfering RNA is a siRNA, shRNA, and/or miRNA, wherein the polynucleotide encoding the antisense or interfering RNA encodes for a siRNA, shRNA, and/or miRNA comprising a single polynucleotide strand, the single polynucleotide strand comprising a nucleotide sequence with at least 85% sequence identity to SEQ ID NO:

• 4 and a nucleotide sequence with at least 85% sequence identity to the complement of SEQ ID NO:
• 4, and wherein the vector is a delivery vector.