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US 12,648,973 B2Granted
Active substance of Lactobacillus plantarum GKM3, a composition comprising thereof and its use for promoting longevity
AssigneeGrape King Bio Ltd.
InventorsChin-Chu Chen, Yen-Lien Chen, Shin-Wei Lin, Yen-Po Chen, Ci-Sian Wang, Yu-Hsin Hou, Yang-Tzu Shih, Ching-Wen Lin, Ya-Jyun Chen, Jia-Lin Jiang
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Abstract
The present invention provides an active substance of Lactic Acid Bacteria, a composition comprising thereof and its use for promoting longevity, especially for increasing Cisd2 gene expression, reducing mitochondrial damage and delaying aging conditions such as nerve degeneration and sarcopenia.
Claims12
A method of increasing Cisd2 gene expression in a subject, comprising:
- administering an effective amount of a composition to a subject;
- wherein the composition comprising an active substance of Lactobacillus plantarum of an effective amount, wherein the Lactobacillus plantarum No. 14565 is deposited at China General Microbiological Culture Collection Center;
- wherein the active substance is prepared by the following method:
- (a) streaking the Lactobacillus plantarum on a solid-state media to produce single colonies;
- and
- (b) inoculating a single colony of the Lactobacillus plantarum cultured at step (a) to a liquid culture for liquid-state culture;
- (c) centrifuging the liquid culture cultured at step (b) to obtain a bacterial pellet;
- and
- (d) freeze-drying the bacterial pellet obtained at step (c);
- wherein the active substance is a freeze-dried Lactobacillus plantarum.
7 more elements
A method of delaying nerve degeneration and sarcopenia in a subject, comprising:
- administering an effective amount of a composition to a subject;
- wherein the composition comprising an active substance of Lactobacillus plantarum of an effective amount, wherein the Lactobacillus plantarum No. 14565 is deposited at China General Microbiological Culture Collection Center;
- wherein the active substance is prepared by the following method:
- (a) streaking the Lactobacillus plantarum on a solid-state media to produce single colonies;
- and
- (b) inoculating a single colony of the Lactobacillus plantarum cultured at step (a) to a liquid culture for liquid-state culture;
- (c) centrifuging the liquid culture cultured at step (b) to obtain a bacterial pellet;
- and
- (d) freeze-drying the bacterial pellet obtained at step (c);
- wherein the active substance is a freeze-dried Lactobacillus plantarum.
7 more elements
Dependencies are inferred from the claim text.