Compositions and methods of treatment comprising tumor-targeting bacteria and chemotherapy or immunotherapy agent
AssigneeThe Curators of the University of Missouri
InventorsChiswili Yves Chabu, Bakul Dhagat, Robert Kazmierczak
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Abstract
The present disclosure relates to a composition of a biologically pure isolate of the genus Salmonella comprising archival strain CRC1674, wherein the isolate further comprises a disruption of at least one gene selected from the group consisting of aroA, rfaH, and thyA and a chemotherapy agent, an immunotherapy agent, an androgen receptor antagonist, or a combination thereof. The present disclosure also relates to the method of use of this composition in treating cancer, particularly prostate cancer and pancreatic cancer.
Claims20
A method for treating cancer in a patient in need thereof, the method comprising administering an effective amount of a biologically pure isolate of the genus Salmonella comprising archival strain CRC1674, wherein the isolate further comprises a disruption of at least one gene selected from the group consisting of aroA gene, rfaH gene, and thyA gene, and an agent of (i) a chemotherapy agent, (ii) an immunotherapy agent, or (iii) a chemotherapy and immunotherapy agent.
A method for treating prostate cancer in a patient in need thereof, the method comprising administering an effective amount of a biologically pure isolate of the genus Salmonella comprising archival strain CRC1674, wherein the isolate further comprises a disruption of at least one gene selected from the group consisting of aroA gene, rfaH gene, and thyA gene and an agent of (i) a chemotherapy agent, (ii) an androgen receptor antagonist, or (iii) a chemotherapy agent and androgen receptor antagonist.
Dependencies are inferred from the claim text.