Fibroblast and fibroblast-immunocyte combinations for treatment of subconcussive- and concussive-associated neurological damage

A method of treating a sub-concussive or concussive brain injury in an individual, comprising the steps of:

• a) optionally identifying an individual with one or more elevated inflammatory markers subsequent to a head and/or neck injury;
• b) administering a therapeutically sufficient amount of regenerative cells and/or one or more products derived from said regenerative cells;
• wherein said regenerative cells comprise fibroblasts, fibroblasts and hematopoietic stem cells (HSCs), fibroblasts and mesenchymal stem cells (MSCs), and/or fibroblasts and monocytes,
• wherein the inflammatory markers are selected from the group consisting of:
• a) C-reactive protein;
• b) interleukin-1;
• c) interleukin-6;
• d) interleukin-8;
• e) interleukin- 33;
• f) erythrocyte sedimentation ratio;
• g) TNF-alpha;
• h) interferon-gamma;
• and i) a combination thereof,
• wherein the inflammatory markers are elevated compared to an individual without a sub-concussive or concussive brain injury or a value in the general population,
• wherein the one or more products derived from said regenerative cells comprise conditioned media, cellular lysate, apoptotic bodies, exosomes, microvesicles, or a combination thereof.