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US 12,648,964 B2Granted
Chimeric Tim receptors and uses thereof
AssigneeCero Therapeutics Holdings, Inc.
InventorsDaniel Mark Corey, Nathan Kipniss
Life of this patent
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Abstract
The present disclosure relates to chimeric Tim receptors, host cells modified to include chimeric Tim receptor molecules, and methods of making and using such receptor molecules and modified cells.
Claims22
A chimeric engulfment receptor comprising a single chain chimeric protein, the single chain chimeric protein comprising:
- (a) an extracellular domain comprising a binding domain comprising:
- a Tim4 IgG V domain and a Tim4 mucin domain;
- (b) an intracellular signaling domain, wherein the intracellular signaling domain comprises a CD28 signaling domain, a CD3ζ signaling domain, and a TLR2 signaling domain;
- and
- (c) a CD28 transmembrane domain positioned between and connecting the extracellular domain and the intracellular signaling domain.
2 more elements
Dependencies are inferred from the claim text.