Compositions and methods for providing cardioprotective effects
AssigneeCornell University
InventorsLorraine J Gudas, Xiao-Han Tang
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Abstract
The invention provides compositions and methods for providing a cardioprotective effect in a subject. Specifically, the invention provides compositions and methods for treating cardiovascular ailments, for example, ischemia/reperfusion (I/R) injury, cardiac arrhythmias, oxidative stress, or cardiac failure by administering a retinoic acid receptor-beta (RARβ) agonist.
Claims4
A method for reducing myocardial injury to a heart of a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a retinoic acid receptor-beta (RARβ) agonist, wherein the RARβ agonist is AC261066 having a structure of Formula 1:
- or the RARB agonist is AC55649 having a structure of Formula 2:
Dependencies are inferred from the claim text.