Polymeric nanocarriers and methods of use thereof
AssigneeVanderbilt University
InventorsCraig L Duvall, Joseph Paul Vanderburgh, Mukesh K. Gupta, Scott A. Guelcher, Julie A. Rhoades
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Abstract
A polymeric nanocarrier and method of treating a bone disease are provided. The polymeric nanocarrier includes an amphiphilic copolymer including a hydrophobic block and a hydrophilic block, where the hydrophilic block comprises a random copolymer. The method of treating a bone disease includes administering the polymeric nanocarrier to a subject in need thereof.
Claims13
A polymeric nanocarrier micelle, comprising (poly(propylene sulfide)135-b-((alendronate)x-co-(poly(N,N-dimethylacrylamide))y)150;
- wherein x is between 3 and 15 and y is between 135 and 147.
A polymeric nanocarrier comprising (poly(propylene sulfide))135-b-((alendronate)x-co-(poly(N,N-dimethylacrylamide))y)150;
- wherein x is between 3 and 15 and y is between 135 and 147.
A method of treating a bone disease, the method comprising administering a polymeric nanocarrier to a subject in need thereof, the polymeric nanocarrier micelle comprising (poly(propylene sulfide))135-b-((alendronate)x-co-(poly(N,N-dimethylacrylamide))y)150;
- wherein x is between 3 and 15 and y is between 135 and 147;
- wherein the administration is intravenous.
Dependencies are inferred from the claim text.